Hong LI;Zhi Yuan ZHOU;Rong Yang DAI;Bo LUO;Xiao Li ZHENG;Wen Li YANG;Tao HE;Ming Lu WU
Journal of Systems Science and Complexity. 2004, 17(3): 349-368.
In cells, the interactions of distinct signaling transduction pathways originating
from cross-talkings between signaling molecules give rise to the formation of signaling
transduction networks, which contributes to the changes (emergency) of kinetic behaviors
of signaling system compared with single molecule or pathway. Depending on the known
experimental data, we have constructed a model for complex cellular signaling
transduction system, which is derived from signaling transduction of epidermal growth
factor receptor in neuron. By the computational simulating methods, the self-adaptive
controls of this system have been investigated. We find that this model exhibits a
relatively stable self-adaptive system, especially to over-stimulation of agonist, and
the amplitude and duration of signaling intermediates in it could be controlled by
multiple self-adaptive effects, such as ``signal scattering", ``positive feedback",
``negative feedback" and ``B-Raf shunt". Our results provide an approach to understanding
the dynamic behaviors of complex biological systems.