In this paper, we extend the subsampling method under the linear model to the nonparametric regression model and propose two subsampling methods for the nonparametric local polynomial regression model. First, we derive the convergence rate of subsampling based weighted least squares parameter estimation to full sample weighted least squares parameter estimation, and the asymptotic normality of the subsample parameter estimation are derived. Then, we use the criterion of minimizing the asymptotic variance, and two subsampling methods of OPT and PL under nonparametric local polynomial regression model are proposed. Finally, numerical simulation of OPT subsampling and PL subsampling, uniform subsampling and Basic Leveraging subsampling are carried out respectively, in terms of mean square error, fitting effect and computational cost. The results show that the subsampling method based on OPT criterion and PL criterion has great advantages in improving estimation accuracy and reducing calculation burden.