In order to solve the problem that the dynamic performance of Boost converter is not very ideal when it is disturbed by external disturbance, a control strategy of Boost converter based on extended state observer is proposed. The mathematical model of the converter control system is established. Observing the disturbance caused by the load current and the change of input voltage, the change of the output voltage is estimated and compensated by the extended state observer, and the PD fuzzy logic controller is introduced to improve the dynamic performance of the system. It can accurately estimate the disturbance of the system and compensate for the variation of load current and input voltage online through the strategy, which does not depend on the mathematical model of the control system and the specific parameters. Simulation and experimental results show that the proposed control strategy is effective.