Case-based reasoning (CBR) is an important reasoning technique of expert system. In this paper, the authors introduce CBR to intelligent early-warning support system, which could warn quantitatively for enterprise financial crisis and could warn qualitatively by expert’s knowledge and experience. Furthermore, genetic algorithm is applied to case-based reasoning in CBR-IEWSS, which improves accuracy and efficiency of case retrieval. Last, the structure of CBR-IEWSS is given.